Directed shift of vaginal microbiota induced by vaginal application of sucrose gel in rhesus macaques
نویسندگان
چکیده
منابع مشابه
Prevention of Vaginal Shiv Transmission in Rhesus Macaques through Inhibition
mune compromise occurs very early in the diseases process. Of great importance is the failure of long-term ( 5 years) highly active retroviral therapy to reverse this sitespecific T-cell depletion. Additionally, other studies have demonstrated that HIV is consistently detectable in the intestine of HIV-infected patients, even those with no detectable plasma virus. Current therapies are inadequa...
متن کاملCyclic changes in the vaginal epithelium of normal rhesus macaques.
Studies in nonhuman primates indicate that changes in the thickness and integrity of the vaginal epithelium affect the transmission rates of HIV-1, but few studies have examined the normal variations that may occur in the vagina of normal macaques as a result of aging or changes in the menstrual cycle. This study was conducted to determine if differences occur in the thickness of the vaginal mu...
متن کاملPharmacokinetics of a CCR5 inhibitor in rhesus macaques following vaginal, rectal and oral application.
OBJECTIVES This study measured and compared the pharmacokinetics of CMPD167, a small molecule antiretroviral CCR5 inhibitor with potential as an HIV microbicide, following vaginal, rectal and oral administration in rhesus macaques. METHODS A vaginal hydroxyethylcellulose (HEC) gel, a rectal HEC gel, a silicone elastomer matrix-type vaginal ring and an oral solution, each containing CMPD167, w...
متن کاملPrevention of vaginal SHIV transmission in rhesus macaques through inhibition of CCR5.
Topical agents, such as microbicides, that can protect against human immunodeficiency virus (HIV) transmission are urgently needed. Using a chimeric simian/human immunodeficiency virus (SHIV SF162), which is tropic for the chemokine receptor CCR5, we report that topical application of high doses of PSC-RANTES, an amino terminus-modified analog of the chemokine RANTES, provided potent protection...
متن کاملTwice-Daily Application of HIV Microbicides Alters the Vaginal Microbiota
UNLABELLED Vaginal HIV microbicides offer great promise in preventing HIV transmission, but failures of phase 3 clinical trials, in which microbicide-treated subjects had an increased risk of HIV transmission, raised concerns about endpoints used to evaluate microbicide safety. A possible explanation for the increased transmission risk is that the agents shifted the vaginal bacterial community,...
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ژورنال
عنوان ژورنال: International Journal of Infectious Diseases
سال: 2015
ISSN: 1201-9712
DOI: 10.1016/j.ijid.2014.12.040